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Our systematic analysis provides new insight into the recurrent genomic alterations associated with telomere maintenance mechanisms in cancer. Telomeres are nucleoprotein complexes at the ends of chromosomes that prevent DNA degradation and genome instability 1. Telomeres play an important role in cellular aging, as they are shortened with each cell division and finally trigger a DNA damage response resulting in senescence 4 , 5. To avoid this permanent growth arrest, cells with unlimited proliferative potential need to extend their telomeres.
This complex is active in the germline and stem cells, but absent in most somatic cells 6. The remaining tumors employ an alternative lengthening of telomeres ALT pathway, which is based on DNA recombination of telomeric sequences Telomeres of ALT cells characteristically have heterogeneous lengths and contain a range of telomere variant repeats TVRs 13 , 14 ,